The University of Iowa

IMPORTANT: The Optical Science and Technology Center and Microfabrication Facility are being retired after fall 2018 and their services reconfigured under the new Iowa Center for Research, Exploration, and Advanced Technology in Engineering and Sciences (Iowa-CREATES) and Materials Analysis, Testing, and Fabrication (MATFab) in the Iowa Advanced Technology Laboratories (IATL) in spring 2019. As a result, the OSTC/UIMF site will eventually be taken down. Until then, please visit the Iowa-CREATES Website at, or read more about the new center at


Optical Science and
Technology Center

OSTC Seminar- "Opto Analytical Sensing, Imaging and Stimulation (OASIS)"

104 Iowa Advanced Technology Laboratories (IATL)

Wei-Chuan Shih

Associate Professor
Departments of Electrical & Computer Engineering,
Biomedical Engineering, and Chemistry
University of Houston

Abstract  Light matter interaction can provide rich constitutional information in tissue, cells, and molecules. Our laboratory at University of Houston has developed several opto-analytical sensing, imaging and stimulation (OASIS) technologies with core innovations in material, device, and instrumentation. In this talk, I will discuss label-free Raman spectroscopy and hyperspectral Raman imaging for non-invasive chemical measurements in cell, tissue, animal, and human. Next, I will present our work in developing a unique class of plasmonic nanomaterial, nanoporous gold disks (NPGD), featuring ~100 nm particle size with 3- dimensionally distributed and interconnected porous network of ~10 nm pore size. I will provide an overview on various aspects of this novel functional material such as fabrication, characterization, modeling, and applications. Specifically, I will discuss several advanced techniques with strong translational potential in the biomedical and environmental fields. I will then discuss our strategies for implementing these techniques on a novel multi-modal neural probe platform designed for stimulation and sensing in the deep brain region. I will close by showcasing our highly publicized DotLens Smartphone/Tablet Microscopy and its value in formal and informal K-12 STEM education, citizen science, as well as practical and research applications.

Download flyer

Individuals with disabilities are encouraged to attend all University of Iowa sponsored events. If you are a person with a disability who requires an accommodation in order to attend this program, please contact the Optical Science & Technology Center in advance at 353-0974 or email